A O01 Ursodeoxycholic acid for the prevention of gall stones after laparoscopic sleeve gastrectomy: a prospective controlled study

Abstract Background Obesity is a risk factor for cholelithiasis. Besides, rapid weight loss after bariatric surgery upsurges the rate of cholelithiasis and acute cholecystitis. This study aimed to compare gallstone development frequency LSG under ursodeoxycholic acid (UDCA) prophylaxis. Methods prospective controlled included 332 patients scheduled randomized receive 500 mg UDCA daily 12 months (UDCA Group) or no treatment (Control Group). Ultrasonography was done 6 detect gallstones. Cholecystectomy complicated cases Results Seventy-one were lost follow-up, 3 developed severe adverse effects excluded. Data are presented 130 in group 128 Control group. Collectively, 11 (8.5%) 41 (32.0%) gall stones during first postoperative year (p < 0.001). indicated (2.3%) 9 (7.0%) = 0.072). On multivariate analysis, higher BMI, dyslipidemia, lacking prophylaxis independent factors significantly associated with stone development. Also, months. Conclusions once effective reducing formation at 1 year. administration reduced cholecystectomies from 7 2.3%. High BMI dyslipidemia preoperative